Clen-Plex 100 combines the long-acting stimulant bronchodilator clenbuterol with caffeine (stimulant) and aspirin (adjuvant) for oral use. Clenbuterol exerts its effects by agonizing beta-2-adrenergic receptors, resulting in bronchodilation and increased metabolic activity.
Clen-Plex 100 is indicated in patients where bronchodilation and potent increases in basal metabolic activity are clinically desirable.
Clen-Plex 100 contains clenbuterol hydrochloride, caffeine, and aspirin for oral use. Clenbuterol is a beta-2-adrenergic agonist relaxing airway muscle tissue and providing bronchodilation. Clenbuterol increases aerobic capacity, pulse, perspiration, and blood pressure; increasing basal metabolic rate and temperature. Caffeine is a xanthine alkaloid derivative and CNS stimulant. Aspirin is a salicylate drug with antipyretic, anti-platelet, and anti-inflammatory properties. Caffeine and aspirin act as adjuvants potentiating the action of clenbuterol.
Clen-Plex 100 exerts a pronounced action on the metabolism; with both anabolic and anti-catabolic effects. Clenbuterol has been demonstrated to increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio. Clenbuterol has an oral bioavailability of 89 to 98 percent with a half-life of 36 to 48 hours after oral use.
Clenbuterol may enhance the action and side effects of other beta-adrenergic mimetics, theophylline, and anti-cholinergics.
Beta-blockers may inhibit the action of clenbuterol; thus a risk of bronchospasm exists with concomitant treatment.
Clenbuterol may alter the action of hypoglycemic agents, insulin sensitizers, insulin, and insulin secretagogues. Adjustment of dosage may be required. Monitor for loss of glycemic control.
There is an increased risk of arrhythmia with concomitant administration of chalogenated carbohydrates for narcosis; e.g. during surgery.
Concomitant use with diuretics and digitalis glycosides requires periodic monitoring of serum electrolytes.
Concomitant use with other CNS stimulants should be avoided given the cumulative stimulatory effects and increased risk of adverse events.
Concomitant use with MAO-inhibitors and tri-cyclic antidepressants may produce cardiac dysrhythmias.
Not for use with children or geriatric patients.
Clenbuterol should not be used by women who are pregnant or may become pregnant.
Not for use in patients with cardiovascular disease, hypertension, or history of cardiovascular events.
Not for use in patients with current or historical myocardial infarction; liver or renal insufficiency; tachycardia, other cardiac dysrhythmias, myocarditis, mitral valve prolapse, hypokalemia or unmanaged diabetes.
Not for use in patients with elevated intraocular pressure, adrenal tumors, or hyperthyroidism.
Not to be used concomitantly with other CNS stimulants, adrenergic, or hypertensive agents.
Not to be used in patients with hypersensitivity to clenbuterol, caffeine, aspirin or other ingredients.
Not to be used in patients with a history of GI bleeding, ulceration of the stomach, or gastritis.
Keep out of the reach of children. In case of accidental ingestion, contact a physician immediately.
Clen-Plex 100 can produce significant cardiovascular effects in some patients as evidenced by elevated pulse rate, blood pressure changes and/or ECG changes. Clen-Plex 100 patients should be monitored for changes in heart rate, arterial blood pressure, and/or oxygen saturation of arterial blood.
Clenbuterol overdose may be characterized by: tremor of the fingers, significant sweating, headache, and tachycardia. Extreme and severe overdose cases have presented with collapse, seizures, coma, and death. In cases of overdose, clenbuterol use should be discontinued. Stomach lavage with activated charcoal, forced diuresis, and symptomatic therapy should be performed. In doses higher than prescribed, clenbuterol may aggravate existing asthma. In all such cases, seek emergency medical assistance.
DOSAGE AND ADMINISTRATION
As prescribed by physician: Maximum dosage of 1 tablet orally per day.
Uncoated tablets: 100 tablets in blisters.
Protect from light. Store at 15 - 25oC.
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